NIDA-CTN-0084
Division
HEAL Study
Investigator(s)
Title
Developing a Prescription Opioid Registry across Diverse Health Systems
Short Description
The purpose of this study is to develop a prescription opioid registry across ten diverse health systems with harmonized electronic health record (EHR) data, and leverage it to answer several key ‘next step’ research questions in response to the opioid crisis. The registry will include medications prescribed for treatment of OUD, including buprenorphine products.
Release Date
Jan 08, 2026
Description
The study establishes a prescription opioid registry using EHR dispensation data from 2012-2017 across 10 health systems to identify algorithms and data elements that will be harmonized in a distributed data architecture. The registry will be used in the following aims.
A. examine opioid use patterns over 2012-2017 to examine changes during the evolving prescribing environment. We will examine differences in rates by age, gender, and race/ethnicity.
B. examine categories of tapering (e.g. decreased opioid use) among prescription opioid patients, and whether faster taper rates are associated with adverse events (e.g. overdose, mortality).
C. examine if patients with SUD or psychiatric conditions are less like to taper opioid use, compared to patients without those conditions.
D. examine how dispensations post-surgery and for acute pain are related to subsequent long term opioid use and opioid dosage levels, which are risk factors for OUD and overdose.
Phase 2. analysis to identify different measures of buprenorphine retention, and explore the methods needed to examine the association to mortality rates.
A. examine opioid use patterns over 2012-2017 to examine changes during the evolving prescribing environment. We will examine differences in rates by age, gender, and race/ethnicity.
B. examine categories of tapering (e.g. decreased opioid use) among prescription opioid patients, and whether faster taper rates are associated with adverse events (e.g. overdose, mortality).
C. examine if patients with SUD or psychiatric conditions are less like to taper opioid use, compared to patients without those conditions.
D. examine how dispensations post-surgery and for acute pain are related to subsequent long term opioid use and opioid dosage levels, which are risk factors for OUD and overdose.
Phase 2. analysis to identify different measures of buprenorphine retention, and explore the methods needed to examine the association to mortality rates.
Keywords
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