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NIDA-CTN-0003

Division

CTN

HEAL Study

Investigator(s)

Walter Ling, M.D.

Title

Suboxone (Buprenorphine/Naloxone) Taper: A Comparison of Two Schedules

Short Description

To compare the clinical utility of two dosage tapering regimens in Buprenorphine/Naloxone stabilized subjects for opiate detoxification.

Release Date

May 29, 2008

Description

For decades clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, one of the most effective means to achieving that goal, has been unavailable outside the very restrictive confines of narcotic treatment programs (NTPs). A new medication, buprenorphine, shows promise as an effective aid for opiate detoxification. However, little data have been generated for the shorter-term use of buprenorphine/naloxone for this indication. This protocol will compare the clinical utility of two dosage tapering regimens in buprenorphine/naloxone stabilized subjects for opiate detoxification.

Keywords

Assessments

Addiction Severity Index Lite

Adjective Rating Scale for Withdrawal

Clinical Opiate Withdrawal Scale

DSM-IV ADHD Symptom Checklist

Risk Behavior Survey

Visual Analog Scales