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NIDA-CTO-0003

Division

DTMC

HEAL Study

Investigator(s)

Thomas F. Newton, M.D.

Title

Assessment Of Potential Interactions Between Intravenous Cocaine And Tolcapone

Short Description

This is a human laboratory clinical pharmacology study to assess potential interactions between intravenous cocaine infusion and treatment with tolcapone.

Release Date

Aug 01, 2016

Description

The primary objective of this study is to determine the safety of tolcapone treatment, compared to placebo treatment, concurrent with i.v. cocaine infusions of 20 and 40 mg, with the focus being on cardiovascular responses (HR, BP) to the i.v. cocaine infusions.

Keywords

Assessments

Addiction Research Center Inventory

Blood Cocaine Level

Blood Study Agent Level

Brief Symptom Inventory

ECG Monitoring