NIDA-CSP-1021

Division

HEAL Study

Investigator(s)

Title

Double-Blind, Placebo-Controlled Multi-Center Trial Of Baclofen For The Treatment Of Cocaine Dependence

Short Description

To assess the efficacy and safety of baclofen in reducing cocaine use in subjects with cocaine dependence. It is hypothesized that baclofen treatment, compared to placebo, will be associated with fewer days of cocaine use as assessed by self-report confirmed with urine assays for benzoylecgonine (BE).

Release Date

May 07, 2018

Description

The primary objective of this study is to assess the efficacy of baclofen in reducing cocaine use in subjects with cocaine dependence (DSM-IV criteria). The hypothesis is that baclofen will reduce cocaine use over the treatment period as compared to placebo as determined by selfreport confirmed with urine assays for BE.

Keywords

Assessments

Addiction Severity Index Lite

Brief Substance Craving Scale

Clinical Global Impression Scales

Cocaine Selective Severity Assessment

Hamilton – Depression Rating Scale

HIV Risk-Taking Behaviour Scale