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NIDA-CPU-0006

Division

DTMC

HEAL Study

Investigator(s)

Reese Jones, M.D.

Title

A Phase 1 Parallel-Group, Double-Blind, Placebo-Controlled Cardiovascular and Behavioral Study Assessing Interactions Between Single Doses of Oral Reserpine and Intravenous Methamphetamine

Short Description

In this parallel group clinical pharmacology laboratory experiment, we will assess pharmacodynamic interactions (with a focus on cardiovascular effects) of a 15 mg intravenous methamphetamine dose and single oral doses of reserpine (0.5 and 1.0 mg) or placebo.

Release Date

May 23, 2017

Description

This 7-day double-blind, parallel-group, placebo-controlled inpatient study will compare the effects of 15 mg of intravenous methamphetamine given 60 hours before and 12 hours after a single oral dose of reserpine (0.5 or 1.0 mg) or placebo.

Keywords

Assessments

Addiction Research Center Inventory

Brief Substance Craving Scale

Change in Sexual Function Questionnaire

ECG Monitoring

McLean Hospital Event Overt Aggression Checklist