NIDA-CPU-0010

This is a dose escalating, double-blind, placebo-controlled inpatient study in 16 cocaine-experienced volunteers. The subjects will receive atomoxetine 20 mg once daily (q.d.) for 2 days, 40 mg q.d. for 2 days, 80 mg q.d. for 5 days and 100 mg q.d. for 5 days orally or matched placebo. After beginning daily treatment with either atomoxetine or placebo, subjects will receive treatment cocaine infusions of 20 mg and 40 mg i.v. on the two last days of 80 mg and 100 mg atomoxetine dosage levels. Each cocaine infusion will be preceded or followed by saline i.v. infusion in random order; cocaine and saline infusions will be administered 60 minutes apart. The subjects will be discharged 4 days after the last infusion of cocaine (day 17). Subjects will be requested to return for follow-up 2 weeks after the day of discharge.