NIDA-CTN-0037

This was a randomized, controlled trial that enrolled 302 participants diagnosed with stimulant abuse or dependence that began substance use treatment in a residential setting. Participants were randomized to one of two treatment arms: 1) usual care augmented with Vigorous Intensity High Dose Exercise (VIHD) and 2) usual care augmented with Health Education Intervention (HEI). Participants received three months of acute phase intervention followed by an additional six months of intervention with less frequent supervision. The primary aim of the study was to compare percent days of abstinence between the VIHD and HEI groups based on stimulant use during the 12-week acute phase. The study also evaluated a number of secondary outcome measures.