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NIDA-CTN-0097

Division

CTN

HEAL Study

Yes

Investigator(s)

Adam Bisaga, M.D.

Edward V. Nunes, M.D.

Title

Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone (SWIFT)

Short Description

This study compares two methods of initiating treatment with extended-release naltrexone (XR-NTX) when implemented at community-based inpatient or residential programs.

Release Date

Feb 11, 2025

Description

This study compares two methods of initiating treatment with extended-release naltrexone (XR-NTX) when implemented at community-based inpatient or residential programs. The primary goal of this hybrid effectiveness-implementation study is to determine whether the Rapid method of initiating treatment with XR-NTX is non-inferior to a standard method on the primary effectiveness outcome of successful initiation of XR-NTX (receiving the first injection while inpatient) when implemented at community-based inpatient or residential programs. Secondary objectives include comparing rapid versus standard method of XR-NTX initiation on: time from admission to first dose of XR-NTX while inpatient and time to dropout, craving, withdrawal severity, retention, abstinence, and safety measures.

Keywords

buprenorphine

community treatment programs

naltrexone

opiate

Assessments

Clinical Opiate Withdrawal Scale

Subjective Opiate Withdrawal Scale

Time Line Follow Back

Visual Analog Scales