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NIDA-CTN-0101

Division

CTN

HEAL Study

Yes

Investigator(s)

Jane Liebschutz, M.D., M.P.H.

Jennifer McNeely, M.D.

Title

Subthreshold Opioid Use Disorder Prevention (STOP) Trial

Short Description

The Subthreshold Opioid Use Disorder Prevention (STOP) trial will test the efficacy of a primary care intervention to reduce opioid use and overdose risk, and prevent progression to OUD, in adults with unhealthy use of illicit or prescribed opioids

Release Date

Oct 27, 2025

Description

A cluster-randomized trial, conducted in 5 primary care sites, with 100 PCPs and 300adult primary care patients, will test the efficacy of STOP versus enhanced usual care (EUC). The STOP intervention, if proven efficacious, will provide a solution to preventing OUD among patients who are most at risk, thus addressing a key aspect of the current opioid crisis

Keywords

collaborative care model

opiate

Primary Care

Assessments

Brief Pain Inventory

Overdose Risk Behavior Questionnaire

Patient Health Questionnaire

Psychiatric Diagnostic Screening Questionnaire

SF-36 and SF-12 Health Status Questionnaire

Time Line Follow Back