To obtain access to any datasets listed on this site, you must first receive approval from NIDA Datashare's Data Access Committee (DAC).

Please submit your request by sending your request to NIDA_Datashare_DAC@mail.nih.gov along with the following information:

Your name, title, and organization
Study Number and Study Title
The specific dataset(s) you are requesting
The intended use or purpose of the data
Willingness to comply with the NIDA Datashare Registration Agreement

Once your request is reviewed, you will receive instructions on how to proceed.

Thank you for your cooperation.

NIDA-CTO-0006

Division

DTMC

HEAL Study

Investigator(s)

Bonita Singal, M.D.

T. John Winhusen, Ph.D.

Title

Cocaine-Metyrapone Interaction Study

Short Description

The primary goal of this study is to evaluate the safety of conducting an outpatient MRP study in which participants would be given two 750 mg doses of MRP per week.

Release Date

Aug 01, 2016

Description

The primary objectives of this study are:
1. To demonstrate that a 750 mg dose of MRP is safe when used concomitantly with cocaine.
2. To demonstrate that a 750 mg dose of MRP is safe to use two days in a row.
3. To determine whether MRP can block the cocaine craving and physiological symptoms induced by cocaine cues (i.e., CR).
4. To determine whether MRP can block the cocaine craving and physiological symptoms induced by a personal stress situation (i.e., SI).
5. To determine whether MRP can modify the subjective and physiologic effects of cocaine.

Keywords

Assessments

Addiction Severity Index Lite

ECG Monitoring

HIV Risk-Taking Behaviour Scale

Visual Analog Scales

Vital Signs Monitoring