A measure to document tobacco use, including lifetime use, 30-day quantity and frequency, and age of first use. Questions are based on the PhenX Toolkit's Alcohol, Tobacco and Other Substances domain.

A Sexual Risk Behaviors assessment administered at screening, mid-treatment, and end-of-treatment, to assess engagement in risky sexual behaviors in the past 30 days prior to each assessment. Participants will answer questions about the number and sex of sexual partners, HIV status of partners, and use of condoms as well as the use of drugs and alcohol during sex.

A Quality of Life assessment using items from the PhenX Core Tier 1. Participants will be asked to provide ratings of general health, physical health, and mental health during the past 30 days at screening, mid-treatment, and end-of-treatment.

The PDSQ is a 112 item, self-administered, psychiatric screening tool which has been tested extensively in primary care and general psychiatric populations. It was designed to screen for 13 DSM-IV disorders in five areas. The final version of the questionnaire contains 13 subscales (major depressive disorder [MDD], bulimia, post-traumatic stress disorder [PTSD], panic disorder, agoraphobia, social phobia, generalized anxiety disorder [GAD], obsessive-compulsive disorder [OCD], alcohol abuse/dependence, drug abuse/dependence, somatization, hypochondriasis, and psychosis). Additionally, there is a six-item psychosis screen.

This DSM-5 Checklist has been designed as a semi-structured interviewer-administered instrument that provides current diagnoses for substance use disorders based on DSM-5 diagnostic criteria.

A measure to document any alcohol use, illicit drug use (e.g. illegal, more than prescribed, not prescribed), and any marijuana use. The participant is asked whether he/she has ever used alcohol and/or various substances as well as his/her age when the substance was first used. Questions are based on the PhenX Toolkit's Alcohol, Tobacco and Other Substances domain.