This was a randomized, controlled trial in which 538 participants were recruited from 12 sites to participate in a study comparing treatment as usual plus smoking-cessation (TAU+SCT) to substance abuse treatment as usual alone (TAU). The purpose of this study was to evaluate whether concurrent smoking-cessation treatment improves, worsens, or has no effect on stimulant-use outcomes in smokers who are in outpatient substance-abuse treatment for cocaine or methamphetamine dependence. The study also evaluated: 1. the impact of TAU+SCT, relative to TAU, on other drug-abuse outcomes; 2. the efficacy of TAU+SCT, relative to TAU, in improving smoking outcomes; and 3. whether achieving complete smoking abstinence is associated with improved stimulant use outcomes.

This was a randomized, controlled trial in which 507 participants in outpatient treatment for substance use disorders were recruited from ten sites to participate in a study comparing 1) treatment as usual (TAU) to 2) a modification of TAU, which included access to the Therapeutic Education System (TES), a computerized psychosocial intervention which combines skill building modules based on the Community Reinforcement Approach (CRA) with incentives contingent upon abstinence from drugs and completion of TES modules. The purpose of this study was to evaluate the relative effectiveness of the interventions on the primary outcomes of a) drug abstinence during active treatment and b) treatment retention. The study also evaluated a number of secondary outcome measures.

This was a randomized, controlled trial that enrolled 302 participants diagnosed with stimulant abuse or dependence that began substance use treatment in a residential setting. Participants were randomized to one of two treatment arms: 1) usual care augmented with Vigorous Intensity High Dose Exercise (VIHD) and 2) usual care augmented with Health Education Intervention (HEI). Participants received three months of acute phase intervention followed by an additional six months of intervention with less frequent supervision. The primary aim of the study was to compare percent days of abstinence between the VIHD and HEI groups based on stimulant use during the 12-week acute phase. The study also evaluated a number of secondary outcome measures.

This was a randomized, controlled trial in which 5012 participants seeking medical or health services from nine STD clinics were enrolled in a study comparing 1) on-site HIV rapid testing with brief, participant-tailored prevention counseling vs. 2) on-site HIV rapid testing with information only. The purpose of this study was to explore whether the provision of counseling reduced risk behavior and sexually transmitted infections over time. In addition to HIV, participants were screened for sexually transmitted infections at the baseline visit and the 6-month follow-up visit.

This was a randomized, controlled clinical trial in which 1,281 adults receiving drug abuse treatment were recruited from 12 sites to participate in an HIV testing and counseling study. The purpose of this study was to assess the relative effectiveness of three HIV testing strategies on increasing receipt of test results: (1) on-site HIV rapid testing with brief, participant-tailored prevention counseling, (2) on-site HIV rapid testing with information only, and (3) referral for off-site HIV testing. The study also assessed the effectiveness of the three testing strategies in reducing HIV risk behaviors. Injection drug risk behavior was also assessed.

This was an ancillary study to CTN-0031, a randomized controlled trial of Stimulant Abuser Groups to Engage in 12-Step (STAGE-12). 219 participants from 3 sites who were randomized in the CTN-0031 study were eligible for the ancillary study, in which neurocognitive testing was performed and a blood sample was obtained for the assessment of oxidative stress/damage. The purpose of the ancillary study was to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with methamphetamine use disorders. The study also evaluated performance on additional neurocognitive measures and the level of oxidative damage and the impact of each of these on stimulant use outcomes.

This was a randomized, controlled clinical trial in which 471 stimulant abusers were recruited from 10 sites to participate in study comparing 12-Step (STAGE-12) plus treatment as usual (TAU) to TAU alone. The purpose of this study was to evaluate reduction in percent of days of stimulant use as measured by self-report. The study also evaluated reduction in percent days of use of other substances, the degree to which STAGE-12 increased involvement in 12-step activities and attendance at 12-step meetings, and the extent to which such 12-step involvement and meeting attendance mediated substance use outcomes.

This was an ancillary study to CTN-0030, a two-phase randomized controlled clinical trial of buprenorphine/naloxone treatment plus individual drug counseling for opioid analgesic dependence. All participants (648) randomized to Phase 1 of the CTN-0030 study were eligible for the ancillary study. Participants were assessed via telephone at 1.5, 2.5, and 3.5 years post-Phase 1 randomization into the CTN-0030 study. The study evaluated opioid use, quality of life, and pain.

Patients with prescription opioid dependence may be able to benefit from pharmacological treatments shown to be effective in heroin addicts. Clinical research has established BUP as a safe and effective alternative to methadone. The primary objective of this study is to determine whether the addition of individual drug counseling to the prescription of buprenorphine/naloxone along with Standard Medical Management for subjects dependent on prescription opioid analgesics improves outcome both during a) an initial four-week treatment with taper and b) a 12-week stabilization treatment for those who do not respond successfully to the initial treatment with taper.

Adult ADHD is a common and impairing neuro-psychiatric disorder, affecting approximating seven to eight millions adults in the United States. Substance use disorders, including cigarette smoking and nicotine dependence, are some of the more common co-morbid disorders with adult ADHD. Studies have found that adults with ADHD are twice as likely to smoke cigarettes and be dependent on nicotine than adults without ADHD.